FOXD3 and malignant colon neoplasm: Moreover, a study also showed that the FOXD3 gene could induce tumor cell apoptosis under the endoplasmic reticulum stress through p53 [23], while another study showed that FOXD3 could inhibit the cellular proliferation of colon cancer cells and activate the EGFR/ERK signaling pathway, thereby acting as a tumor suppressor [27]; these results were also consistent with the current study results.