TARDBP and early-onset autosomal dominant Alzheimer disease: This idea is supported by previous studies that have found inverse correlations between the primary pathology and age, such as between age and tau deposition in Alzheimer’s disease.20,40,41 An alternative explanation for an inverse correlation between disease stage and age is that more neuronal death in older (or more progressed) subjects leads to lower proportions of TDP-43 pathology being stained on histopathological slides.