NLRP3 and endothelial dysfunction: NLRP3 inflammasome‐mediated pyroptosis has been shown to closely associate with endothelial membrane rupture and cell lysis, releasing various cellular contents including pro‐inflammatory cytokines and high‐mobility group box 1 which further exacerbate endothelial dysfunction by increasing cell permeability and disrupting endothelial junctions.[38] These effects are likely to occur naturally in control implants potentially explaining the enhanced re‐endothelialization of MCC950 grafts compared to control.