CDH5 and endothelial dysfunction: VE‐cadherin is an endothelial specific adhesion molecule essential to controlling the integrity and permeability of junctions within the healing vessel endothelium.[26] The healing endothelium also requires functional eNOS to synthesize nitric oxide which plays numerous central roles from the regulation of vascular tone to injury recovery.[27] Reduced expression of both markers are key indicators of endothelial dysfunction.