CD40LG and autoimmune neuropathy: Taking ganglioside‐containing liposomes as an example, naturally occurring low‐affinity anti‐GM ganglioside IgM antibodies (mainly anti‐GM1) are part of the normal antibody repertoire of healthy humans.[45] However, in the plasma of patients with autoimmune neuropathies like Guillain–Barré Syndrome, elevated titers of high‐affinity anti‐GM IgM antibodies are detected.[46, 47] When the GM1‐liposomes are exposed to blood, the complement system is activated through the classical pathway.