Amplification or overexpression of TP63 are frequently observed in squamous cell carcinoma, including LUSC [13, 14], and ectopic expression of the ΔNp63 isoform (ΔNp63) has been shown to drive to the development of squamous metaplasia in the mouse lung and promote proliferative phenotypes in skin epithelial basal cells [15, 16]. Here, TP63 is linked to squamous cell carcinoma.