Other studies have reported neuroprotective effects of WIN55,212–2 on striatal neurons of a 6-OHDA PD model by altering the ERK1/2 phosphorylation status [132] and in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model by suppressing microglial activation [133]. The gene discussed is MAPK3; the disease is Parkinson disease.