RHOT1 and Parkinson disease: Removal of Miro1 from depolarized and dysfunctional mitochondria is now being explored as a novel neuroprotective mechanism against PD, as reducing Miro1 levels has been shown to improve mitochondrial arrest and thereby mitophagy and prevent dopaminergic neuronal loss in iPSC-derived human neurons and Drosophila PD models without significant effects on the movement of healthy mitochondria [47, 50].