Numerous studies have shown that increasing E-cadherin expression can reverse EMT, a cellular program critical for tumor malignant progression that is characterized by the loss of epithelial phenotype and the acquisition of mesenchymal phenotype.29–31 Therefore, we analyzed how cell morphology changed in irradiated and non-irradiated pEcad-GVs@C6 cells. This evidence concerns the gene CDH1 and neoplasm.