The acoustic control of nuclear E-cadherin delivery significantly prolonged the survival of tumor-bearing rats, achieving 52.3 ± 6.9, 41.8 ± 6.8 and 44.9 ± 6.9 days mean survival time for the SynG2/M-, SynG1-, or SynS-irradiated groups, respectively, compared to the synchronized non-irradiated group and wild type control group (Fig. 5j). This evidence concerns the gene CDH1 and neoplasm.