These findings suggested that the enhanced inhibitory effects of E-cadherin overexpression on tumor invasion and migration could be attributed to Fam50a down-regulation during the SynG2/M phase, which would result in reduced nuclear translocation of the Fam50a/Runx2 complexes and decreased the transcription of MMP13 (Fig. 6v). This evidence concerns the gene RUNX2 and neoplasm.