The cell cycle is a fundamental process required for cell growth and division that is governed by the spatiotemporal regulation of gene expression and protein function.32,33 Because E-cadherin expression can be spatiotemporally controlled by ultrasound-triggered intracellular cavitation for nuclear gene delivery, we wonder what effects its overexpression would have on tumor invasion and metastasis if it occurred at different cell cycle phases. Here, CDH1 is linked to neoplasm.