Numerous studies have shown that MMP13, a matrix metalloproteinase, plays an important role in EMT in many tumors and has a strong correlation with invasive carcinomas.44,45 Several studies have found that MMP13 can reduce tumor cell adhesion by degrading the extracellular matrix, thereby facilitating tumor cell invasion and metastasis.46,47 Thus, our findings suggest that the increased tumor invasion and migration inhibition effects of E-cadherin during the G2/M phase may be due to the deactivation of the Fam50a/Runx2-MMP13 axis. Here, RUNX2 is linked to invasive carcinoma.