Previous research has shown that Fam50a can interact directly with Runt-related transcription factor 2 (Runx2), a member of the runt homology domain family.34 Recent research has discovered that Runx2 plays a critical role in tumor cell invasion and migration.35–37 Therefore, we hypothesize that E-cadherin inhibits tumor invasion and metastasis via the Fam50a/Runx2 pathway. Here, RUNX2 is linked to neoplasm.