Moreover, there is evidence that STS inhibition alone can have anti-inflammatory effects (Reed et al., 2005), so there was also the possibility of synergistic effects using STX140, especially given that in a collagen-induced arthritis model evidence was obtained showing that progression was markedly altered by the STS inhibitor estrone 3-O-sulfamate (Foulkes et al 1997). This evidence concerns the gene STS and Arthritis.