PLIN5 and cardiac hypertrophy: MRI revealed a similar ejection fraction of Plin5-Tg mice compared to controls at the age of 4 months (Fig. 2C) despite a signature of cardiac hypertrophy and adverse cardiac remodeling including an increase in LV mass, LV posterior wall thickness, and relative wall thickness in Plin5-Tg mice (Fig. 2, D–F).