IL6 and plasma cell myeloma: We previously demonstrated the capacity of CDDO‐Im to induce apoptosis in human multiple myeloma (MM) cells [13], through mechanisms that included suppression either of the constitutive or of the interleukin 6 (IL‐6) induced phosphorylation of signal transducers and activators of transcription (STATs), specifically STAT3 and STAT5.