All three “OTUD4-modules” contained terms such as “ubiquitin protein ligase activity”, the FTLD2-blue module also showed enrichment of the GO term “ribonucleoprotein granule”, indicating that other genes in this module might also have processes relevant to granule formation, as with the meta-analysis hit OTUD4. Ubiquitin signalling is well described as a process implicated in neurodegenerative disease pathology, and several genes involved in ubiquitin and ubiquitin binding processes are known to be mutated/contain risk alleles in multiple neurodegenerative diseases, including FTD [69]. This evidence concerns the gene OTUD4 and neurodegenerative disease.