Therefore, it is worth noting that the development of therapeutic tools based on PA8 as recombinant or gene therapy using secreted PA8, which target the PrPC–AβO interaction and could reduce not only AβO but also rescued its associated downstream signaling which subsequently prevent neuroinflammation and neurodegeneration, will be advantageous in the successful development of effective therapeutics for AD and other incurable protein misfolding neurodegenerative diseases. Here, PRNP is linked to Alzheimer disease.