Two CpGs (cg03169557 [near the genes RPL13 and SPG7] and cg05066959 [near the genes NKX6-3, ANK1, and MIR486]) were significantly associated with both AD case–control status and AD Braak stage and were already described in previous DNAm AD studies [8, 16–18]. This evidence concerns the gene SPG7 and Alzheimer disease.