PRF1 and Alzheimer disease: Regarding the other novel signals of our EWAS, we note that although no direct evidence exists linking either LIPE (encoding lipase E [a.k.a. hormone sensitive lipase {HSL}], near CpG cg03073402 on chromosome 19p) or PRF1 (encoding perforin 1; near CpG cg20648333 on chromosome 10q) to AD, both genes are involved in molecular pathways, i.e. lipid metabolism [43] and the immune system response [44], respectively, which are both highly relevant in AD pathogenesis based on recent GWAS data [45, 46].