We treated GCT cell lines GCT44 and 1411H (YST), NTERA-2 (EC) and TCam2 (seminoma) with two different WNT inhibitors: the tankyrase inhibitor IWR-1 (Fig. 6a) and the PORCN inhibitor LGK-974 (Fig. 6b). Here, PORCN is linked to granular cell tumor.