ISG15 and neoplasm: For example, Cheng et al.10 defined several tumor associated macrophage types including ISG15 + , SPP1 + , INHBA + , VCAN + , NLRP3 + , and FN1 + macrophages, while Bi et al.43 defined CXCL10-high, GPNMB-high, FOLR2-high, VSIR-high, and cycling macrophages for advanced renal cell carcinoma (ccRCC).