Compared with Cdh5 Cre-; Wwp2fl/fl mice, endothelial-specific Wwp2 knockout mice (Cdh5 Cre + ; Wwp2fl/fl mice) showed elevated endothelial DDX3X expression under both normal conditions (Additional file 1: Fig. S3A, B) and T2DM conditions (Additional file 1: Fig. S3C, D), confirming that WWP2 reduces the protein level of DDX3X in vivo. Here, DDX3X is linked to type 2 diabetes mellitus.