Now that we have established that the down-regulation of WWP2 exacerbates T2DM-induced vascular endothelial injury, we then addressed two aspects: first, to elucidate how endothelial WWP2 expression is down-regulated in during T2DM, and second, to explore how WWP2 regulates T2DM-induced vascular endothelial injury. This evidence concerns the gene WWP2 and type 2 diabetes mellitus.