WWP2 and type 2 diabetes mellitus: Now that we have established that the down-regulation of WWP2 aggravates T2DM-induced vascular endothelial injury, our next objective in the current study was to address two aspects: first, to elucidate how endothelial WWP2 expression is down-regulated in during T2DM, and second, to explore how WWP2 regulates T2DM-induced vascular endothelial injury.