Our research has revealed a novel mechanism (Fig. 7) by which MSI2 exerts its pro-proliferative properties via the MSI2/DLL1/Notch1 cascade and metastatic properties via the MSI2/Snail1/MMPs axis in AML, and miR-143 as a negative regulator of MSI2 can serve as a tumor suppressor to predict prognosis and develop personalized treatment strategies for AML patients. The gene discussed is NOTCH1; the disease is neoplasm.