In our experiment, MSI2 knockdown significantly inhibited the migration of AML cells, while overexpression of MSI2 showed the opposite effect by upregulating Snail1 protein level and subsequent expression of MMPs, which confirmed our hypothesis that MSI2 facilitated migration of AML cells by activating the MSI2/Snail1/MMPs axis. This evidence concerns the gene SNAI1 and acute myeloid leukemia.