Moreover, silencing of MSI2 significantly impaired the clonogenic capacity (Fig. 3E and Additional file 1: Fig. S4D) and accelerated apoptosis (Additional file 1: Fig. S4E) in three AML cell lines including KG-1α, HL-60, HEL, as well as primary AML cells. The gene discussed is MSI2; the disease is acute myeloid leukemia.