NOTCH4 and breast carcinoma: Although higher expression of Notch4 mRNA is seemingly associated with poorer OS and RFS in breast cancer and TNBC patients without lymph node metastasis (Fig. 1D, H), lower expression of Notch4 mRNA is seemingly correlated with poorer OS and RFS in breast cancer and TNBC patients with lymph node metastasis (Fig. 1E, I).