NOTCH4 and breast carcinoma: Surprisingly, the depletion of Notch4 in TNBC cells shifted the location of Vimentin location from clustered on one side by the nucleus to distributed diffusely around the nucleus, implying that Notch4 knockdown in TNBC cells rendered Vimentin location around the nucleus uniformly and inhibited metastasis of breast cancer (Fig. 3C).