Belonging to the nuclear receptor family, the androgen receptor (AR) shares genetic similarities with other well characterized receptors such as estrogen receptor (ER), progesterone receptor (PR), glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) that are prominently involved in cancers such as breast, ovarian and prostate cancers, to name a few. Here, ESR1 is linked to Familial prostate cancer.