To this end, we analysed the ventral horn of the spinal cord of FTD and wildtype animals at PND365 using Nissl staining (to quantify the number of spinal motor neurons) and GFAP and Iba-1 immunostaining (to detect glial reactivity), and the data strongly indicated no differences between FTD and wildtype mice in any of these parameters (Additional file 8: Fig. S8), which is concordant with the general lack of motor effects in FTD mice at this longer age described above. Here, AIF1 is linked to frontotemporal dementia.