In addition, we conducted double-labelling immunofluorescence between Sox-2 and GFAP and found a reduced ratio of colocalization in FTD mice, whereas Ki67 immunostaining, which is used as a marker of cell proliferation, indicated that this event, rather than being elevated, appeared to be lower in FTD mice (Additional file 6: Fig. S6). The gene discussed is GFAP; the disease is frontotemporal dementia.