Our results confirmed the benefits of FAAH inhibition, since we found significant improvements in the behaviours altered in FTD mice after treatment with URB597, as well as in the loss of pyramidal neurons and associated astroglial and microglial reactivities visible in the mPFC (URB597 reduced both astrogliosis and microgliosis), and the hippocampus (the reduction was restricted to microgliosis). This evidence concerns the gene FAAH and frontotemporal dementia.