Our data proved an elevation in IL-1β expression in FTD mice at PND90 in the mPFC and at PND365 in the hippocampus (p = 0.09), whereas the opposite changes (reduction in the mPFC at PND90 and in the hippocampus at PND365) were evident for arginase-1, possibly indicating a greater M1/A1 profile for microglial/astroglial cells at PND90 in the mPFC, but this occurred at PND365 in the hippocampus. This evidence concerns the gene ARG1 and frontotemporal dementia.