In this sense, some studies have suggested that the effects of a local elevation of anandamide levels induced by URB597 would be predominantly exerted by the activation of CB1 receptors [29, 59], since the highest levels of FAAH are found in those CNS areas in which the CB1 receptor is also more concentrated (e.g., neocortex, hippocampus; [15, 16]), areas that correspond to those structures more affected in FTD. This evidence concerns the gene FAAH and frontotemporal dementia.