TARDBP and frontotemporal dementia: We have confirmed that these behavioural abnormalities appear at early adulthood (PND90) and are associated with neuronal loss (likely caused by TDP-43 aggregation in forebrain neurons which triggers different neurotoxic events) and glial reactivity occurring at two key CNS structures: the mPFC and  the hippocampus, which play important regulatory roles in the brain functions mentioned above (e.g., cognitive processes, social interaction, emotional responses) that are altered in FTD.