For example, in an experimental model of ALS based on overexpression of mutant TDP-43, FAAH expression was reduced in the spinal cord in parallel to elevated levels of 2-AG [18], whereas NAPE-PLD and the levels of anandamide resulted to be increased also in the spinal cord of the ALS murine model based on mutant SOD-1 [5, 54, 84]. Here, FAAH is linked to amyotrophic lateral sclerosis.