The analysis of some morphological aspects of microglial cells in the mPFC of FTD mice revealed that Iba-1-labelled cells had greater cell bodies and shorter branches (indicating an activated phenotype) compared to the smaller cell bodies and longer and thin processes (indicating a more quiescent phenotype) seen in wildtype mice (see inlets in Fig. 6C). This evidence concerns the gene AIF1 and frontotemporal dementia.