CASP3 and frontotemporal dementia: As in the mPFC, we also investigated whether hippocampal neuronal losses seen in FTD mice are associated with elevated levels of caspase-3, but, in this structure, which is a mixture of different subareas, ones having losses (CA1 and dentate gyrus) but others no (CA2-CA3), we only detected a trend towards an increase at PND90 (Fig. 7E,F).