It is important to remark that apathy, depression or anhedonia have been also found in other FTD murine models, for example those based on overexpression of mutant Tau (also under the CaMKIIα promoter) or in GRN-deficient mice that show cytosolic TDP-43 aggregates [23, 40]. The gene discussed is TARDBP; the disease is frontotemporal dementia.