Such reduction also happened in the number of Ctip2-positive cells in the whole mPFC (genotype: F(1,25) = 21.24, p < 0.0001; Fig. 5A,C) and, in particular, in the layer V (genotype: F(1,18) = 17.26, p < 0.001; Fig. 5A,D), in which the pyramidal neurons that connect with subcortical areas are located, and this was observed again in these two structures at both PND90 and PND365 in FTD mice (Fig. 5A,C,D). The gene discussed is BCL11B; the disease is frontotemporal dementia.