In FTD, these inclusions, in which the TDP-43 protein appears hyperphosphorylated, ubiquitinated and/or partially cleaved, are located mainly in the prefrontal cortex, the dentate gyrus of the hippocampus, and the striatum, leading to intense atrophy of the frontal and temporal lobes accompanied by gliosis and hippocampal sclerosis [76]. The gene discussed is TARDBP; the disease is frontotemporal dementia.