Thus, we observed an important reduction by FAAH inhibition in the elevated levels of Iba-1 immunoreactivity found in FTD mice in both the CA1 subfield (F(2,21) = 13.82, p < 0.0001; Fig. 17A,B) and, to a lower extent (only a trend with the posthoc analysis), the dentate gyrus (F(2,20) = 4.401, p < 0.05; Fig. 17A,C), which correlates with the fact that neuronal loss almost did not exist in this hippocampal subarea in this experiment. Here, FAAH is linked to frontotemporal dementia.