Compared to patients with grade 0-1 CRS, patients with grade ≥ 2 CRS had a higher PSI of CD4+ CAR T-cells, especially PSI of IL-8 and MCP-1 [57], which are involved in the recruitment of neutrophils and monocytes/macrophages [110, 111]. This evidence concerns the gene CCL2 and congenital rubella syndrome.