CD8A and neoplasm: Similarly, scRNA-seq suggested that CAR T-cells overexpressing superkine IL-2 (Super2) and IL-33 (Super2+ IL-33 CAR T-cells) could induce the conversion of M2-like macrophages to M1-like macrophages that highly express antigen presentation genes in TME, upregulate the ratio between CD8+ effector T cells and immunosuppressive Tregs, recruit and activate endogenous innate and adaptive immune cells, including tumor-specific T cells.