CD4 and cancer: The heatmap depicting the immune responses based on EpiC, xCell, MCPcounter, QuanTIseq, CIBERSORT − ABS, CIBERSORT, and TIMER, is presented in Fig. 14A. These findings illustrated that patients having high riskScore exhibited an accumulation of tumor-infiltrating immune cells, including T cell regulatory (Tregs), Macrophage M2, T cell CD4 + , as well as cancer-related fibroblast.