Biogenic AgNPs (14 nm) synthesized from Podophyllum hexandrum Royle extracts are considered very effective against HeLa cells for inducing genotoxicity as well as caspase-3 mediated apoptosis [176]; likewise, AgNPs synthesized from Azadirachta indica extracts have been found to induce cytotoxicity and increased caspase-3 expression in HCT-116 human colon cancer cells [6]. This evidence concerns the gene CASP3 and malignant colon neoplasm.