For example, in a study on xenograft mouse model for PCa bone metastasis, chitosan NPs coated miR34a led to the downregulation of multiple gene products (MET, AXL, and C-Myc) that play a significant role in PCa progression and metastasis, not only inhibiting PCa growth but also preserving bone integrity by MiR-34a-induced non-canonical autophagy and apoptosis, lastly leading to tumor growth inhibition [78]. This evidence concerns the gene MET and posterior cortical atrophy.