SIRT1 and cancer: From data available to date, miR34a is reported to target around 700 genes to regulate cell proliferation (NOTCH-1, MDMX, Myc-N), apoptosis (Bcl-2, SIRT-1, BIRC-5), senescence (E2F3), cancer stemness (CD-44, Nanog, Sox-2), immunity (PD-L1, DGK), and where the downregulation of miR34a have evidenced a strong molecular association with cancer onset [33].