PFKFB3 and isolated hemihyperplasia: Molecular biology and cell biology experiments revealed that knocking down 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) could inhibit IH vascularization and migration by affecting glycolytic metabolism and inducing cell apoptosis via apoptotic pathways, implying that targeting PFKFB3 could be a new treatment strategy for IH.