Through the EPIC, MCPCOUNTER and TIDE algorithms, it was found that KCTD5 expression is positively correlated with infiltration by CAFs in ACC (Rho = 0.451, P = 6.32e-05), KIRC (Rho = 0.207, P = 7.66e-06), KIRP (Rho = 0.374, P = 5.44e-10), LIHC (Rho = 0.47, P = 2.11e-20), LUAD (Rho = 0.397, P = 4.70e-20), MESO (Rho = 0.424, P = 5.30e-05), SKCM (Rho = 0.237, P = 3.09e-07), SKCM-metastasis (Rho = 0.267, P = 3.45e-07) and THCA (Rho = 0.255, P = 1.08e-08) (Fig. 6). This evidence concerns the gene KCTD5 and adrenal cortex carcinoma.