Therefore, we hypothesized that these two contradictory roles of DKK3 related to the Wnt/β-catenin pathway (either activating or inhibiting β-catenin) in LGG may have a dual impact on the prognosis of glioma by causing proliferation of glioma cells while maintaining the immune microenvironment of glioma. The gene discussed is DKK3; the disease is glioma.