The results suggested that the AF type (OR = 1.857, 95%CI1.169-2.951, p = 0.009), previous stroke (OR = 1.924, 95%CI1.058-3.499, p = 0.032), Fib (OR = 1.636, 95%CI1.278-2.094, p < 0.001), LA (OR = 1.094, 95%CI1.058-1.131, p < 0.001), LVEF (OR = 0.938, 95%CI0.916-0.960, p < 0.001), and maximum caliber of LAA (OR = 1.238, 95%CI1.149-1.334, p < 0.001) were independent risk factors of LAA thrombosis and SEC in NVAF patients (p < 0.05, Fig. 2). The gene discussed is FBL; the disease is Stroke.