Among the enriched pathways that potentially could contribute to the pathology of PCOS are insulin resistance (e.g., FOXO1, MTOR, GYS1, PTEN, RPS6KB1, STAT3, CREB5, TRIB3), sex differentiation (e.g., FER, FOXF2, LRP2, PGR, SIRT1, LHX9, AGO4), response to hormone (e.g., KLF9, GABRB1, ITGA3, BCAR3, CYP7B1), regulation of cellular catabolic process (e.g., ABCA2, ABCD1, PIK3CA, DISC1, MAP3K5), and GnRH secretion (e.g., ITPR1, PIK3CA, PIK3R1, PLCB4, PIK3R3). This evidence concerns the gene RPS6KB1 and Insulin resistance.