Among the enriched pathways that potentially could contribute to the pathology of PCOS are insulin resistance (e.g., FOXO1, MTOR, GYS1, PTEN, RPS6KB1, STAT3, CREB5, TRIB3), sex differentiation (e.g., FER, FOXF2, LRP2, PGR, SIRT1, LHX9, AGO4), response to hormone (e.g., KLF9, GABRB1, ITGA3, BCAR3, CYP7B1), regulation of cellular catabolic process (e.g., ABCA2, ABCD1, PIK3CA, DISC1, MAP3K5), and GnRH secretion (e.g., ITPR1, PIK3CA, PIK3R1, PLCB4, PIK3R3). The gene discussed is AGO4; the disease is polycystic ovary syndrome.