For example, in PCOS-sons, EDN1, the target gene of hsa-miR-4685-3p, has been shown to be dysregulated in granulosa cells of women with PCOS; CDK6, the target gene of hsa-miR-1299, is a cell cycle marker likely to be involved in the development of PCOS; FRS2, a target gene of hsa-miR-96-5p, has been reported to be upregulated in obese women with PCOS and involved in insulin signaling; and ETS1, a target gene of hsa-miR-1299, is involved in androgen-mediated DNA methylation in granulosa cells in PCOS. The gene discussed is INS; the disease is polycystic ovary syndrome.