The present results suggest that TPPU topical administration targeting sEH can be considered a potential therapeutic strategy for oral ulcers by exerting multiple biological effects of EETs, including shortening healing time, reducing inflammatory cell infiltration, promoting angiogenesis, enhancing cell migration and proliferation, which provides new ideas for the treatment and prevention of clinical oral ulcers. The gene discussed is EPHX2; the disease is Oral ulcer.