To gain some further insight into its pan‐cancer activity, we examined monepantel in CellTiter‐Glo (CTG) luminescent viability assays in over 20 cell lines ranging across melanoma, lung, breast, brain, colorectal, prostate, and ovarian, as well as SV40 Large T‐transformed mouse embryonic fibroblasts (MEFs). This evidence concerns the gene TBXT and melanoma.