BAK1 and colonic neoplasm: As HCT 116 colon cancer cells showed obvious early/intermediate apoptotic populations following monepantel treatment suggestive of apoptosis induction rather than necrosis or some other mode of cell death, we next tested the effect of monepantel on an isogenic derivative of HCT 116 cells that were doubly deficient (“DKO”) for BAX and BAK (BAX−/−BAK−/− cells) (Figure 2B,E).