For example, PPARγ activation by pioglitazone reduced the incidence of AMI or stroke in patients with insulin resistance however, according to the prespecified sub-analysis the beneficial effect was present especially in patients with lesser grade insulin resistance (HOMA-IR < 4.6) and lower glycated haemoglobin concentrations (HBA1C < 5.7%) [43]. This evidence concerns the gene PPARG and stroke disorder.