PTGS2 and neoplasm: For instance, the body exposure to certain carcinogens that alter the responsiveness of cells to the environment to provide a proliferative advantage for cancerous cells, and some bacterial toxins through bad DNA causes genetic mutations, etc. In addition Fusarium foetida is able to adhere to oral mucosal tissues, induce host organism immune response, and cause cyclooxygenase 2 (COX-2) overexpression, thus inhibiting programmed tumor cell death and eventually allowing tumor cells to continue to divide [57].