Homozygous variants in MRPS22 (Chen et al. 2018a) have been reported in non-syndromic POI patients, whereas variants in MRPS7 (Menezes et al. 2015) have been described in a patient with failure of pubertal development and hypogonadism, emphasizing the role of these genes in ovarian development. Here, MRPS7 is linked to hypogonadism.