This is the case for a Native American haplotype within the SLC16A11 gene identified as the main genetic contributor to type 2 diabetes in the Latino population [1, 4], a rare risk variant within HNF1A unique to Latino population [2] and a loss-of-function (LoF) Latino-enriched variant within IGF2 associated with a 22% decrease in the odds of type 2 diabetes in heterozygous carriers [3]. This evidence concerns the gene HNF1A and type 2 diabetes mellitus.