CACNA1S and myotonic dystrophy type 1: It will be interesting to evaluate whether the Ca2+ current facilitation we have identified becomes more frequent and/or more pronounced in muscle fibers obtained from animals subjected to forced exercise (running), or derived from differences in muscle fibers type (i.e., IIa vs. IIx, the predominant fibers types in FDB muscles, Tarpey et al., 2018), or if it is more prominent in diseased models with CaV1.1 gain of function, such as myotonic dystrophy type 1 (Tang et al., 2012).