Another study showed that in a 3D tumor/tumor-associated macrophage (TAM)/T-cell organoid culture used to mimic TME and the immunosuppressive function of TAMs, anti-mesothelin CAR-MAIT cells could successfully retain their anti-tumor potency, probably by direct targeting TAMs via their NK-activating receptors and TCRs [123]. Here, MSLN is linked to neoplasm.