IL15 and neoplasm: They further modified hiPSC-derived CAR-T (CAR-iT) cells with diacylglycerol kinase (DGK) knockout to enhance the CD3ζ-mediated signal pathway and proliferation of CAR-iT cells as well as with genes encoding for membrane-bound IL-15 and its receptor IL-15Rα (IL-15/IL-15Rα) to improve the persistence and anti-tumor effect of CAR-iT cells.