However, these authors hypothesized that the development of the androgen receptor-mediated reproductive PCOS-like traits is not mediated via the NK3R in the Dihydrotestosterone (DHT)-induced PCOS mouse model, or NK3R may indeed be involved, but the antagonist was unable to overcome the chronically elevated DHT of the model [66]. The gene discussed is AR; the disease is polycystic ovary syndrome.