Sepsis moderately decreased PUFAs contents compared to the control (Figure S9), while the lipid peroxidation metabolites in sepsis hearts, especially those derived from arachidonic acid (ARA) and linoleic acid (LA), were substantially counteracted by melatonin and RORα delivery, not melatonin alone (Fig. 7D-E). The gene discussed is RORA; the disease is Sepsis.