Consistent with findings from mammalian development [54], Wnt5a stimulation phosphorylates Vangl2 at critical functional residues across a panel of breast cancer cell lines (Fig. 1e and Additional file 4: Fig. S2f) and loss of VANGL2 suppresses Dvl2 phosphorylation (Fig. 1f). The gene discussed is DVL2; the disease is breast cancer.