Our observations that Vangl2 mediates breast cancer migration and is required for Wnt5a-mediated cell migration (Fig. 1), combined with previous reports that elevated VANGL2 expression correlates with worsened metastasis-free survival in breast cancer patients [31], suggest that high Vangl expression may result in enhanced cellular migration and aberrant engagement of Wnt/PCP signaling in breast tumors. Here, WNT5A is linked to breast cancer.