Our observations are consistent with a role for Vangl2 in mediating cell motility events critical to developing embryos [12, 59], but conflict with a previous report in which shRNA-mediated knockdown of VANGL2 decreased proliferation of SUM159 and HCC1806 breast cancer cells xenografted into the flanks of NSG mice [31]. The gene discussed is VANGL2; the disease is breast carcinoma.