Despite reports that Vangl2 is highly expressed in 25% of invasive breast cancers [18] and that elevated VANGL2 correlates with advanced-stage disease and decreased metastasis-free survival of breast cancer patients [31], the functional role of Vangl2 in breast cancer malignancy has remained largely unexplored and its contribution to breast cancer metastasis has not been reported. This evidence concerns the gene VANGL2 and breast cancer.