Moreover, DVL3-mediated migration, invasion and sphere formation of CRC cells were abolished by shSOX2 (Fig. 6C–E), and DVL3-induced downregulation of E-cadherin, and upregulations of N-cadherin, CD44 and CD33 were also reversed by knockdown of SOX2 (Fig. 6F). The gene discussed is SOX2; the disease is colorectal carcinoma.