Furthermore, analysis of gastrointestinal tumor data from the TCGA and GTEx database also revealed a statistically significant correlation between the expression of NF1 and YAP1 in CHOL (n = 36, R = 0.687, p = 3.70e-6), LIHC (n = 371, R = 0.690, p = 7.98e-54), PAAD (n = 179, R = 0.538, p = 1.87e-32), and STAD (n = 415, R = 0.640, p = 5.09e-22) (Additional file 6: Fig. S4). Here, NF1 is linked to digestive system neoplasm.