NF1 and neoplasm: The survival analysis was performed using COX regression, considering variables such as age, gender, and tumor-node-metastasis (TNM) stage, revealing that the high NF1 expression group had significantly lower survival compared to the low expression group with a hazard ratio of 1.99 (95% confidence interval, 1.06 to 3.75, P = 0.032) (Fig. 1D).