SP1 and cervical carcinoma: In this study, we investigated the potential mechanisms of Sp1 in cervical tumorigenesis and found that overexpression of Sp1 promotes the proliferation, migration, and invasion and reduces apoptosis of human cervical cancer cells in vitro and in vivo by improving aerobic glycolysis and promoting mitochondrial remodelling by rebuilding the balance between mitofusin and mitofission (Fig. 7).