CRP and bacterial meningitis: Moreover, doctors should not let their guard down, especially for patients with consciousness disorders, CRP ≥ 50 mg/L, and/or isolated G + bacteria, because they are very likely to progress to refractory bacterial meningitis.Appropriate extension of anti-infective course, selection of rational combined anti-infective regimen, active treatment of complications and discovery of underlying etiology may be helpful to improve the prognosis of refractory bacterial meningitis.