Based on our previous research and clinical experience, we selected 23 factors related to refractory outcome or poor prognosis for statistical analysis [30–32] and found that early-stage consciousness disorder, CRP ≥ 50 mg/L, and the isolate bacteria being G + bacteria were independent risk factors for pathogenic positive bacterial meningitis cases to progress to refractory outcomes. The gene discussed is CRP; the disease is bacterial meningitis.