Refractory bacterial meningitis was associated with the following eight clinical indicators (Table 3): disturbance of consciousness, slow pupillary light reflex, CRP ≥ 50 mg/L upon admission, procalcitonin > 30 ng/dL upon admission, CSF WBC count ≥ 500 × 106 cells/L, CSF protein values > 1.0 g/L, CSF glucose content < 1.5 mmol/L, and the isolate bacteria being G + bacteria. Here, CRP is linked to bacterial meningitis.