CRP and anemia (phenotype): Among the laboratory findings, anemia (adjusted HR = 1.852; 95% CI 1.265–2.712)20, high CRP (adjusted HR = 1.520; 95% CI 1.081–2.137)20, and leukocytosis (adjusted OR = 3.440; 95% CI 1.139–10.390)48 were significantly associated with increased radiographic progression after adjusting for covariates in single studies.