The genetic alteration (deep deletion) frequency showed that 1/3rd of the chordoma samples have MTAP loss and CDKN2A, CDKN2B and CDKN2C loss; however, there is no loss in the folate pathway genes in the samples analyzed in personalized oncogenomics cBioPortal (Fig. 1A). Here, CDKN2B is linked to chordoma.