Among the mechanisms studied to transform HAs and promote disease progression in addition to poor prognosis in GBM, is the coupling of Myc and EZH2 overexpression as well as the depletion of retinoblastoma protein (Rb) (Fig. 1 and Supplementary Fig. 3) which was observed in our study [17, 40]. Here, RB1 is linked to glioblastoma.