Eleven HCMV-GBM strains were isolated from GBM tumors which acutely transformed HAs toward CEGBCs with increased EZH2/Myc expression that undergo dedifferentiation towards glioblastoma stem cells with spheroid formation and invasiveness capacities that could be curtailed by GSK343/GCV/TMZ triple therapy. Here, MYC is linked to glioblastoma.