HCMV-IE1 protein detection parallel to stemness markers and the upregulated Myc and EZH2 expression parallel to the detection of lncRNA4.9 gene, lncRNA4.9 and HOTAIR transcripts in cultures infected with the eleven HCMV-GBM strains recapitulates the previously observed molecular phenotype induced by HCMV-DB and BL strains. This evidence concerns the gene MYC and glioblastoma.