Since EZH2 and Myc have been implicated in tumor initiation and proven to impact glioblastoma appearance and development with the two high-risk HCMV DB and BL strains isolated from biological fluids (cervical swab and urine respectively), we evaluated EZH2/Myc expression and recovered HCMV strains directly from GBM biopsies thereby assessing their oncogenic potential. Here, MYC is linked to glioblastoma.