Two relevant genes for the development of early onset PD are Parkin and PINK1, and mutations result in recessively inherited PD, both leading to compromised neuronal ability to remove damaged mitochondria (mitophagy), leading to increased amount of dysfunctional mitochondria, release of mitochondrial damage-associated molecular patterns (mitoDAMPs), and neuroinflammation (Borsche et al. 2021). Here, PRKN is linked to Parkinson disease.