In silico analysis from ccRCC TCGA dataset confirmed significant positive correlations between FN1, MMP7, COL1A1 and UHRF1 with PDK3 expression, and between VAV3 with PDK2 and PDK3 expression, and a negative correlation between EPOR and PDK3 expression, and RGS16 with PDK2 (Supplementary Figs. 2 and 3). The gene discussed is RGS16; the disease is nonpapillary renal cell carcinoma.