In mice models, nasal instillation of Staphylococcus aureus attenuates influenza-mediated lethal inflammation in the lungs by inducing M2 alveolar macrophages24, and Lactobacillus plantarum administration protects against lethal pneumovirus infection in the lungs by TLR2 and NOD2 receptor signaling25. The gene discussed is NOD2; the disease is Pneumovirus Infections.